Concepedia

Varghese John

VJ

43

Publications

4.1K

Citations

26

H-Index

1971

Active since

Affiliations

Buck Institute for Research on Aging(Current)

University of California, Los Angeles

University of California, San Francisco

Sunesis (United States)

National Institute on Aging

Varghese John is an author at Buck Institute for Research on Aging specializing in medicine, pharmacology, and drug discovery.

Top concepts

MedicinePharmacologyBiochemistryDrug DiscoveryNatural SciencesMedicinal ChemistryMolecular PharmacologyNeuroscienceNeuropharmacologyAlzheimer's Disease

Publications per year

1971–2022

43

Publications

43

Purification and cloning of amyloid precursor protein β-secretase from human brain

Sukanto Sinha, John P. Anderson, Robin Barbour et al. · Nature · 1999 · 1.6K citations

Neurodegenerative Diseases, Protein Secretion, Molecular Neuroscience +8

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain

Harry F. Dovey, Varghese John, J. P. Anderson et al. · Journal of Neurochemistry · 2001 · 877 citations · Full text

Protein Secretion, Neurochemical Biomarkers, Amyloid Precursor Protein +17

Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase

Michel Maillard, Roy K. Hom, Timothy E. Benson et al. · Journal of Medicinal Chemistry · 2007 · 110 citations · Full text

Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer’s Disease Brain Tissue Reveals Disease-Associated Signatures

Whitaker Cohn, Mikhail Melnik, Calvin Huang et al. · Frontiers in Pharmacology · 2021 · 106 citations · Full text

Neuroprotective Sirtuin ratio reversed by ApoE4

Veena Theendakara, Alexander Patent, Clare A. Peters Libeu et al. · Proceedings of the National Academy of Sciences · 2013 · 98 citations · Full text

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