Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase

Michel Maillard, Roy K. Hom, Timothy E. Benson, +15

Journal of Medicinal Chemistry

Design of Substrate-Based Inhibitors of Human β-Secretase

Jay S. Tung, David L. Davis, John P. Anderson, +7

Journal of Medicinal Chemistry

Design and Synthesis of Hydroxyethylene-Based Peptidomimetic Inhibitors of Human β-Secretase

Roy K. Hom, Andrea F. Gailunas, Shumeye Mamo, +8

Journal of Medicinal Chemistry

Medicinal ChemistryHuman β-SecretaseBioorganic ChemistryPharmaceutical ScienceBiochemistry +13

Design and Synthesis of Statine-Based Cell-Permeable Peptidomimetic Inhibitors of Human β-Secretase

Roy K. Hom, Larry Y. Fang, Shumeye Mamo, +11

Journal of Medicinal Chemistry

Protein SecretionHuman β-SecretaseBiochemistryG Protein-coupled ReceptorNatural Sciences +11

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model

Anh P. Truong, G. Toth, Gary D. Probst, +30

Bioorganic & Medicinal Chemistry Letters

Pharmacological StudyBiochemistryMedicinePreclinical Animal ModelBace-1 Inhibitor +7

Selective and Brain‐Permeable Polo‐like Kinase‐2 (Plk‐2) Inhibitors That Reduce α‐Synuclein Phosphorylation in Rat Brain

Danielle L. Aubele, Roy K. Hom, Marc Adler, +31

ChemMedChem

Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration

Gary D. Probst, Simeon Bowers, Jennifer M. Sealy, +27

Bioorganic & Medicinal Chemistry Letters

MedicineCell DeathNeuropharmacologyNeuroprotectionNeurology +6

Heterodimeric Bis(amino thiol) Complexes of Oxorhenium(V) That Mimic the Structure of Steroid Hormones. Synthesis and Stereochemical Issues

Roy K. Hom, Dae Yoon, John A. Katzenellenbogen

The Journal of Organic Chemistry

Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor

Simeon Bowers, Anh P. Truong, R. Jeffrey Neitz, +20

Bioorganic & Medicinal Chemistry Letters

Pharmaceutical ScienceTri-substituted ThiopheneBrain PenetrantMedicineJnk Inhibitor +6

Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors

Anh P. Truong, Danielle L. Aubele, Gary D. Probst, +21

Bioorganic & Medicinal Chemistry Letters

Structure–activity RelationshipMedicinal ChemistryPharmaceutical ScienceBiochemistryEfficacious Pyrazole/sulfonamide +9