Concepedia

Epoxide Hydrolases

Epoxide Hydrolase is a hydrolase enzyme that catalyzes the hydrolysis of epoxides to their corresponding diols, distinguishing itself from other hydrolases by its specific substrate selectivity for three-membered cyclic ethers formed as reactive intermediates in xenobiotic metabolism and endogenous signaling pathways.

1.3K

Publications

57.1K

Citations

4.1K

Authors

1K

Institutions

Publications per year

2017–2026

188

Variants

Epoxide Hydrolase

Parents

Publications

1.3K

Human microsomal epoxide hydrolase: genetic poloymorphism and functional expression in <i>vitro</i> of amino acid variants

Christopher Hassett, Lauri Alcher, Jaspreet S. Sidhu et al. · Human Molecular Genetics · 1994 · 496 citations · Full text

, , +15

Soluble Epoxide Hydrolase Regulates Hydrolysis of Vasoactive Epoxyeicosatrienoic Acids

Zhigang Yu, Fengyun Xu, Linn M. Huse et al. · Circulation Research · 2000 · 468 citations

, , +14

Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema

Christopher A. Smith, David J. Harrison · The Lancet · 1997 · 435 citations

, , +8

Targeted Disruption of Soluble Epoxide Hydrolase Reveals a Role in Blood Pressure Regulation

Christopher J. Sinal, Masaaki Miyata, Masahiro Tohkin et al. · Journal of Biological Chemistry · 2000 · 341 citations · Full text

, , +14

Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase

Mehran F. Moghaddam, David F. Grant, Jeffrey M. Cheek et al. · Nature Medicine · 1997 · 310 citations · Full text

, , +14

1–5 of 1.3K

Authors

4.1K

  1. BD
    Bruce D. Hammock

    University of California, Davis, United States

    248 publications · 15.8K citations

    74

    h-index

  2. CM
    Christophe Morisseau

    University of California, Davis, United States

    137 publications · 8.1K citations

    54

    h-index

  3. FO
    Franz Oesch

    Johannes Gutenberg University Mainz, Germany

    63 publications · 3.3K citations

    34

    h-index

  4. AA
    Alain Archelas

    Centre National de la Recherche Scientifique, France

    37 publications · 2K citations

    27

    h-index

  5. MA
    Michael Arand

    Johannes Gutenberg University Mainz, Germany

    34 publications · 2.5K citations

    26

    h-index

1–5 of 4.1K

Institutions

1K

  1. University of California, Davis

    Davis, United States

    71 h-index

    997 publications

    71.1K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    34 h-index

    216 publications

    10.7K citations

  3. Johannes Gutenberg University Mainz

    Mainz, Germany

    27 h-index

    173 publications

    8.7K citations

  4. UC Davis Comprehensive Cancer Center

    Sacramento, United States

    26 h-index

    213 publications

    8.7K citations

  5. National Institutes of Health

    Bethesda, United States

    25 h-index

    100 publications

    8.8K citations

  6. Cancer Research Center

    Columbia, United States

    22 h-index

    110 publications

    10.6K citations

  7. University of Groningen

    Groningen, The Netherlands

    21 h-index

    90 publications

    7.2K citations

  8. University of Washington

    Seattle, United States

    21 h-index

    72 publications

    6.8K citations

1–8 of 1K

Venues

  1. Journal of Biological Chemistry

    JBC · 53 publications · 4.1K citations

    37

    h-index

  2. Biochemical Pharmacology

    51 publications · 1.9K citations

    26

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 28 publications · 2.9K citations

    24

    h-index

  4. Archives of Biochemistry and Biophysics

    ABB · 31 publications · 1.9K citations

    24

    h-index

  5. Bioorganic & Medicinal Chemistry Letters

    29 publications · 904 citations

    22

    h-index

1–5