Concepedia

The T cell differentiation landscape is shaped by tumour mutations in lung cancer

Ehsan Ghorani, James L. Reading, Jake Y. Henry, Marc Robert de Massy, Rachel Rosenthal, Virginia Turati, Kroopa Joshi, Andrew J.S. Furness, Assma Ben Aïssa, Sunil Kumar Saini,

Nature Cancer · 2020 · 102 citations · 76 references

Open access

Concepts

Life SciencesCancer BiologyOncologyCancer GeneticsCell DifferentiationMolecular OncologyLung CancerMalignant NeoplasmsMutational SignaturesT Cell BiologyT Cell DevelopmentT Cell DifferentiationCancer-associated Mutational ProcessesIntra-tumor Mutation DistributionLung CarcinogenesisT Cell Differentiation SignalingT Cell Progenitor DifferentiationTumor Clonal Evolution

References

76

Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

Naiyer A. Rizvi, Matthew D. Hellmann, Alexandra Snyder et al. · Science · 2015 · 7.9K citations

Medicine, Immunology, Oncology +17

The Immune Landscape of Cancer

Vésteinn Thórsson, David L. Gibbs, Scott D. Brown et al. · Immunity · 2018 · 6.2K citations · Full text

Medicine, Immunology, Oncology +17

Dimensionality reduction for visualizing single-cell data using UMAP

Étienne Becht, Leland McInnes, John Healy et al. · Nature Biotechnology · 2018 · 5.8K citations

Computing, Cell Biology, Visualization +12

Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade

Pornpimol Charoentong, Francesca Finotello, Mihaela Angelova et al. · Cell Reports · 2017 · 5.4K citations · Full text

Life Sciences, Immunology, Oncology +17

Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer

Gabriela Bindea, Bernhard Mlecnik, Marie Tosolini et al. · Immunity · 2013 · 4.7K citations · Full text

Medicine, Immunology, Oncology +17