Aging · 2020 · 139 citations · 49 references
Life SciencesNeurobiologyNeuroscienceNeurobiology Of DiseaseNeurodegenerationNeuropharmacologyAlzheimer DiseaseCognitive ImpairmentGut MicrobiotaNeurodegenerative DiseasesNeuroprotectionProbioticsIntestinal Microbiota EffectsIntestinal Microbiota ModulationMemantine NeuroprotectionMicrobial Metabolite AlterationsMicrobiome-gut-brain AxisMicrobiome-gut-brain CommunicationMicrobiota-gut-brain AxisProbiotic Effects On Gut Microbiota
augments the beneficial therapeutic effects of memantine treatment in APP/PS1 mice by remodeling the intestinal microbiota, inhibiting the synthesis of TMAO, and reducing clusterin levels. Our results thus highlight intestinal microbiota as a potential therapeutic target to decrease the risk of AD.
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