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Development of selective mono or dual PROTAC degrader probe of CDK isoforms

Fei Zhou, Luyu Chen, Chao-Guo Cao, Jiang Yu, Xiaojiao Luo, Peiting Zhou, Lifeng Zhao, Wu Du, Jijun Cheng, Yongmei Xie,

European Journal of Medicinal Chemistry · 2019 · 107 citations · 20 references

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20

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

Philip D. Jeffrey, Alicia A. Russo, Kornélia Polyák et al. · Nature · 1995 · 1.4K citations

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Catalytic in vivo protein knockdown by small-molecule PROTACs

Daniel P. Bondeson, Alina Mares, Ian E. Smith et al. · Nature Chemical Biology · 2015 · 1.3K citations · Full text

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Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

Jing Lü, Yimin Qian, Martha Altieri et al. · Chemistry & Biology · 2015 · 1.1K citations · Full text

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Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

Eric S. Fischer, Kerstin Böhm, John R. Lydeard et al. · Nature · 2014 · 1.1K citations · Full text

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Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

Michael Zengerle, Kwok-Ho Chan, Alessio Ciulli · ACS Chemical Biology · 2015 · 1K citations · Full text

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