Eric S. Fischer

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

Eric S. Fischer, Kerstin Böhm, John R. Lydeard et al. · Nature · 2014 · 1K citations · Full text

Plasticity in binding confers selectivity in ligand-induced protein degradation

Radosław P. Nowak, Stephen L. DeAngelo, Dennis L. Buckley et al. · Nature Chemical Biology · 2018 · 609 citations · Full text

Protein Chemistry, Biochemistry, Protein Assembly +5

Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase

Georg Petzold, Eric S. Fischer, Nicolas H. Thomä · Nature · 2016 · 572 citations · Full text

Protein Function, Signal Transduction, Cell Regulation +11

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

Baishan Jiang, Michael A. Erb, Yanke Liang et al. · Nature Chemical Biology · 2017 · 531 citations · Full text

Selective Cdk9 Inhibition, Medicine, Receptor Tyrosine Kinase +4

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

Katherine A. Donovan, An Jian, Radosław P. Nowak et al. · eLife · 2018 · 502 citations · Full text