Concepedia

Plasticity in binding confers selectivity in ligand-induced protein degradation

Radosław P. Nowak, Stephen L. DeAngelo, Dennis L. Buckley, Zhixiang He, Katherine A. Donovan, Jian An, Nozhat Safaee, Mark P. Jedrychowski, Charles M. Ponthier, Mette Ishoey,

Nature Chemical Biology · 2018 · 631 citations · 47 references

Concepts

Life SciencesBiochemistryMolecular BiologyCell SignalingMolecular RecognitionProtein BiochemistryLigand BindingProtein DegradationProtein-ligand BindingProtein-ligand InteractionsProtein-ligand RecognitionReceptor-ligand InteractionsConformational Change Upon BindingLigand Binding SelectivityLigand SelectivityLigand-induced Conformational ChangeSelectivity

References

47

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie, Belinda Phipson, Di Wu et al. · Nucleic Acids Research · 2015 · 43K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +17

<i>Phaser</i>crystallographic software

Airlie J. McCoy, Ralf W. Grosse‐Kunstleve, Paul D. Adams et al. · Journal of Applied Crystallography · 2007 · 20.9K citations · Full text

Natural Sciences, Chemistry, Computational Chemistry +16

Wolfgang Kabsch · Acta Crystallographica Section D Biological Crystallography · 2010 · 16.9K citations · Full text

Computing, Computer Science, Computational Geometry +13

<i>MolProbity</i>: all-atom structure validation for macromolecular crystallography

Vincent B. Chen, W.B. Arendall, Jeffrey J. Headd et al. · Acta Crystallographica Section D Biological Crystallography · 2009 · 14.7K citations · Full text

Life Sciences, Bioinformatics, Biophysics +17

Overview of the<i>CCP</i>4 suite and current developments

Martyn Winn, Charles Ballard, Kevin Cowtan et al. · Acta Crystallographica Section D Biological Crystallography · 2011 · 12.6K citations · Full text

Natural Sciences, Biophysics, Chemistry +16