Katherine A. Donovan

Plasticity in binding confers selectivity in ligand-induced protein degradation

Radosław P. Nowak, Stephen L. DeAngelo, Dennis L. Buckley et al. · Nature Chemical Biology · 2018 · 631 citations

Life Sciences, Biochemistry, Molecular Biology +14

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

Katherine A. Donovan, An Jian, Radosław P. Nowak et al. · eLife · 2018 · 517 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

Mikołaj Słabicki, Zuzanna Kozicka, Georg Petzold et al. · Nature · 2020 · 407 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +11

Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development

Katherine A. Donovan, Fleur M. Ferguson, Jonathan W. Bushman et al. · Cell · 2020 · 371 citations · Full text

Engineering, Bioengineering, Biotechnology +2

Exploring Targeted Degradation Strategy for Oncogenic KRASG12C

Mei Zeng, Yuan Xiong, Nozhat Safaee et al. · Cell chemical biology · 2019 · 275 citations · Full text

Medicine, Molecular Biology, Molecular Genetics +11