Katherine A. Donovan

Plasticity in binding confers selectivity in ligand-induced protein degradation

Radosław P. Nowak, Stephen L. DeAngelo, Dennis L. Buckley et al. · Nature Chemical Biology · 2018 · 609 citations · Full text

Protein Chemistry, Biochemistry, Protein Assembly +5

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

Katherine A. Donovan, An Jian, Radosław P. Nowak et al. · eLife · 2018 · 502 citations · Full text

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

Mikołaj Słabicki, Zuzanna Kozicka, Georg Petzold et al. · Nature · 2020 · 389 citations · Full text

Protein Function, Signal Transduction, Cell Regulation +10

Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development

Katherine A. Donovan, Fleur M. Ferguson, Jonathan W. Bushman et al. · Cell · 2020 · 346 citations · Full text

Geometric Modeling, Robotics, Engineering +11

Exploring Targeted Degradation Strategy for Oncogenic KRASG12C

Mei Zeng, Yuan Xiong, Nozhat Safaee et al. · Cell chemical biology · 2019 · 266 citations · Full text

Oncogenic Agent, Molecular Biology, Degradation Reaction +3