Exploring Targeted Degradation Strategy for Oncogenic KRASG12C

Mei Zeng, Yuan Xiong, Nozhat Safaee, +16

Cell chemical biology

Oncogenic AgentMolecular BiologyDegradation ReactionDegradation StrategyProtein Degradation +1

Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C

Mei Zeng, Jia Lu, Lianbo Li, +16

Cell chemical biology

Medicinal ChemistryKras G12cMedicinePharmacotherapyDrug Development +4

Ceftazidime‐Avibactam Population Pharmacokinetic Modeling and Pharmacodynamic Target Attainment Across Adult Indications and Patient Subgroups

Jianguo Li, Mark Lovern, Michelle Green, +10

Clinical and Translational Science

Chemo-proteomics exploration of HDAC degradability by small molecule degraders

Yuan Xiong, Katherine A. Donovan, Nicholas A. Eleuteri, +6

Cell chemical biology

Proteomic TechnologyBiochemistryProtein FoldingNatural SciencesProteomics +1

A model-based approach to investigating the pathophysiological mechanisms of hypertension and response to antihypertensive therapies: extending the Guyton model

K. Melissa Hallow, Arthur Lo, Jeni Beh, +10

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

HypertensionHeart FailureHypertension PathologyCardiovascular DiseaseMedicine +13

Nonlinear Mixed‐Effects Model Development and Simulation Using nlmixr and Related R Open‐Source Packages

Matthew Fidler, Justin Wilkins, Richard Hooijmaijers, +5

CPT Pharmacometrics & Systems Pharmacology

EngineeringSimulation Using NlmixrPharmacotherapySystem PharmacologyOrdinary Differential Equations +15

Covalent Guanosine Mimetic Inhibitors of G12C KRAS

Yuan Xiong, Jia Lu, John C. Hunter, +9

ACS Medicinal Chemistry Letters

Asymmetric Syntheses of the Flavonoid Diels–Alder Natural Products Sanggenons C and O

Chao Qi, Yuan Xiong, Vincent Eschenbrenner‐Lux, +2

Journal of the American Chemical Society

EngineeringOrganic ChemistryChemistryAsymmetric SynthesesDouble Claisen Rearrangement +14

Population pharmacokinetics of cabotegravir following administration of oral tablet and long‐acting intramuscular injection in adult HIV‐1‐infected and uninfected subjects

Kelong Han, Mark Baker, Mark Lovern, +12

British Journal of Clinical Pharmacology

Structure of a Synaptic gamma-delta Resolvase Tetramer Covalently Linked to two Cleaved DNAs

W. Li, Satwik Kamtekar, Yuan Xiong, +3