Concepedia

Ligand Binding Selectivity

Ligand Binding Selectivity is a biochemical property that characterizes the preferential interaction of a ligand with a specific target biomolecule over other structurally or functionally related biomolecules, typically quantified by differences in binding affinity or efficacy across a panel of targets.

386

Publications

22.7K

Citations

2.1K

Authors

602

Institutions

Publications per year

2017–2026

77

Parents

Publications

386

Plasticity in binding confers selectivity in ligand-induced protein degradation

Radosław P. Nowak, Stephen L. DeAngelo, Dennis L. Buckley et al. · Nature Chemical Biology · 2018 · 631 citations

, , +14

Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains

Bradford Graves, R. Crowther, Chitra Chandran et al. · Nature · 1994 · 397 citations

, , +13

PDZ Domain Binding Selectivity Is Optimized Across the Mouse Proteome

Michael A. Stiffler, Jiunn R Chen, Viara Grantcharova et al. · Science · 2007 · 381 citations · Full text

, , +17

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

Paul A. Clemons, Nicole E. Bodycombe, Hyman A. Carrinski et al. · Proceedings of the National Academy of Sciences · 2010 · 352 citations · Full text

, , +17

DNA Binding Selectivity of MeCP2 Due to a Requirement for A/T Sequences Adjacent to Methyl-CpG

Robert J. Klose, Shireen A. Sarraf, Lars Schmiedeberg et al. · Molecular Cell · 2005 · 343 citations · Full text

, , +13

1–5 of 386

Authors

2.1K

  1. DL
    Dale L. Boger

    Scripps Research Institute, United States

    7 publications · 487 citations

    7

    h-index

  2. RQ
    Rémi Quirion

    Douglas Mental Health University Institute, Canada

    6 publications · 377 citations

    6

    h-index

  3. WD
    W. David Wilson

    Georgia State University, United States

    4 publications · 90 citations

    4

    h-index

  4. JY
    Jae Young Seong

    Korea University, South Korea

    4 publications · 115 citations

    4

    h-index

  5. HE
    H. Eric Xu

    Shanghai Institute of Materia Medica, China

    3 publications · 202 citations

    3

    h-index

1–5 of 2.1K

Institutions

602

  1. Centre National de la Recherche Scientifique

    Paris, France

    14 h-index

    59 publications

    3.1K citations

  2. Scripps Research Institute

    San Diego, United States

    11 h-index

    29 publications

    2.1K citations

  3. Inserm

    Paris, France

    9 h-index

    27 publications

    1.5K citations

  4. University of Copenhagen

    Copenhagen, Denmark

    7 h-index

    31 publications

    1.3K citations

  5. McGill University

    Montreal, Canada

    6 h-index

    17 publications

    619 citations

  6. Harvard University

    Cambridge, United States

    6 h-index

    32 publications

    9.6K citations

  7. Zhejiang University

    Hangzhou, China

    6 h-index

    30 publications

    1.1K citations

  8. Monash University

    Melbourne, Australia

    6 h-index

    23 publications

    921 citations

1–8 of 602

Venues

  1. Journal of Biological Chemistry

    JBC · 29 publications · 2.8K citations

    25

    h-index

  2. Journal of Medicinal Chemistry

    30 publications · 1.6K citations

    24

    h-index

  3. Journal of the American Chemical Society

    JACS · 19 publications · 1.2K citations

    18

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 14 publications · 1.7K citations

    13

    h-index

  5. Molecular Pharmacology

    12 publications · 1K citations

    12

    h-index

1–5