Yimin Qian

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

Jing Lü, Yimin Qian, Martha Altieri et al. · Chemistry & Biology · 2015 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Biology +6

PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

Kanak Raina, Jing Lü, Yimin Qian et al. · Proceedings of the National Academy of Sciences · 2016 · 827 citations · Full text

Medicine, Molecular Biology, Oncology +17

The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study

George M. Burslem, Blake E. Smith, Ashton C. Lai et al. · Cell chemical biology · 2017 · 673 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

Edwina C. Lerner, Yimin Qian, Michelle A. Blaskovich et al. · Journal of Biological Chemistry · 1995 · 360 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53

John Hines, Schan Lartigue, Hanqing Dong et al. · Cancer Research · 2018 · 339 citations

Life Sciences, Molecular Biology, Oncology +14