Edwina C. Lerner

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

Edwina C. Lerner, Yimin Qian, Michelle A. Blaskovich et al. · Journal of Biological Chemistry · 1995 · 359 citations · Full text

Molecular Biology, Cancer Biology, Tumor Biology +17

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

Edwina C. Lerner, Tingting Zhang, David B. Knowles et al. · Oncogene · 1997 · 239 citations

Caax Peptidomimetics, Medicine, Anti-cancer Agent +5

HGF and c-Met Participate in Paracrine Tumorigenic Pathways in Head and Neck Squamous Cell Cancer

Lynn M. Knowles, Laura P. Stabile, Ann Marie Egloff et al. · Clinical Cancer Research · 2009 · 227 citations

Src Kinases Mediate STAT Growth Pathways in Squamous Cell Carcinoma of the Head and Neck

Sichuan Xi, Qing Zhang, Kevin F. Dyer et al. · Journal of Biological Chemistry · 2003 · 182 citations · Full text

Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

Edwina C. Lerner, Yimin Qian, Andrew D. Hamilton et al. · Journal of Biological Chemistry · 1995 · 175 citations · Full text