David B. Knowles

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

Edwina C. Lerner, Tingting Zhang, David B. Knowles et al. · Oncogene · 1997 · 239 citations

Caax Peptidomimetics, Medicine, Anti-cancer Agent +5

Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.

Jiazhi Sun, Michelle A. Blaskovich, David B. Knowles et al. · PubMed · 1999 · 209 citations

Antitumor Efficacy, Pharmacotherapy, Inhibits Tumor Growth +17

Photochromic compounds: Chemistry and application in ophthalmic lenses

John C. Crano, T. Flood, David B. Knowles et al. · Pure and Applied Chemistry · 1996 · 202 citations · Full text

Optical Materials, Engineering, Ophthalmology +6

Comparison of perturbatively corrected energy results from multiple reference double-excitation configuration-interaction method calculations with exact full configuration-interaction benchmark values

David B. Knowles, José Ramón Alvarez Collado, Gerhard Hirsch et al. · The Journal of Chemical Physics · 1990 · 160 citations

Spectral Theory, Numerical Analysis, Engineering +18

Photochromism of Diarylnaphthopyrans

Barry Van Gemert, Maria Bergomi, David B. Knowles · Molecular crystals and liquid crystals science technology. Section A, Molecular crystals and liquid crystals/Molecular crystals and liquid crystals science and technology. Section A, Molecular crystals and liquid crystals · 1994 · 75 citations

Materials Science, Plastic Matrix, Optical Materials +14