Michelle A. Blaskovich

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

Khandaker Siddiquee, Shumin Zhang, Wayne C. Guida et al. · Proceedings of the National Academy of Sciences · 2007 · 743 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +14

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

Michelle A. Blaskovich, Jiazhi Sun, Alan Cantor et al. · PubMed · 2003 · 569 citations

Medicine, Oncology, Pharmacology +15

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

Edwina C. Lerner, Yimin Qian, Michelle A. Blaskovich et al. · Journal of Biological Chemistry · 1995 · 360 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity

Jiazhi Sun, Michelle A. Blaskovich, Richard Jove et al. · Oncogene · 2005 · 262 citations

Medicine, Medicinal Chemistry, Pharmacology +5

Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.

Jiazhi Sun, Michelle A. Blaskovich, David B. Knowles et al. · PubMed · 1999 · 209 citations

Medicine, Oncology, Pharmacology +14