Jiazhi Sun

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

Michelle A. Blaskovich, Jiazhi Sun, Alan Cantor et al. · PubMed · 2003 · 569 citations

Medicine, Oncology, Pharmacology +15

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

Edwina C. Lerner, Yimin Qian, Michelle A. Blaskovich et al. · Journal of Biological Chemistry · 1995 · 360 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity

Jiazhi Sun, Michelle A. Blaskovich, Richard Jove et al. · Oncogene · 2005 · 262 citations

Medicine, Medicinal Chemistry, Pharmacology +5

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

Jiazhi Sun, Yimin Qian, Andrew D. Hamilton et al. · Oncogene · 1998 · 231 citations

Medicine, Molecular Biology, Oncology +13

Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.

Jiazhi Sun, Yimin Qian, Andrew D. Hamilton et al. · PubMed · 1995 · 227 citations

Medicine, Oncology, Pharmacology +17