Concepedia

John Hines

JH

32

Publications

5.9K

Citations

27

H-Index

1971

Active since

Affiliations

Yale University(Current)

Arvinas (United States)

Duke University

Yale Cancer Center

National Cheng Kung University

John Hines is an author at Yale University specializing in medicine, natural sciences, and biochemistry.

Top concepts

MedicineNatural SciencesBiochemistryPharmacologyCell BiologyMolecular BiologyEngineeringProtein DegradationDrug DiscoverySmall Molecules

Publications per year

1971–2024

32

Publications

32

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

Jing Lü, Yimin Qian, Martha Altieri et al. · Chemistry & Biology · 2015 · 1.1K citations · Full text

Natural Sciences, Molecular Biology, Dna Replication +3

Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead

Daniel P. Bondeson, Blake E. Smith, George M. Burslem et al. · Cell chemical biology · 2017 · 867 citations · Full text

Protac Design, Selective Degradation, Biomolecular Engineering +1

The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study

George M. Burslem, Blake E. Smith, Ashton C. Lai et al. · Cell chemical biology · 2017 · 643 citations · Full text

Protein Chemistry, Protein Function, Biochemistry +14

Modular PROTAC Design for the Degradation of Oncogenic BCR‐ABL

Ashton C. Lai, Momar Toure, Doris Hellerschmied et al. · Angewandte Chemie International Edition · 2015 · 606 citations · Full text

HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins

Dennis L. Buckley, Kanak Raina, Nicole Darricarrère et al. · ACS Chemical Biology · 2015 · 455 citations · Full text

Protein Assembly, Molecular Biology, Chemical Biology +18

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