Lactobacillus plantarum C88 protects against aflatoxin B1-induced liver injury in mice via inhibition of NF-κB–mediated inflammatory responses and excessive apoptosis

Abstract

Probiotic L. plantarum C88 prevented AFB₁-induced secretion of pro-inflammatory cytokines by modulating TLR2/NF-κB and TLR4/NF-κB pathways. The molecular mechanisms of L. plantarum C88 in ameliorating AFB₁-induced excessive apoptosis included regulating the mitochondrial pathway and cell death receptor pathways.