Concepedia

TREM2 function impedes tau seeding in neuritic plaques

Cheryl E. G. Leyns, Maud Gratuze, Sneha Narasimhan, Nimansha Jain, Lauren J. Koscal, Hong Jiang, Melissa Manis, Marco Colonna, Virginia M.‐Y. Lee, Jason D. Ulrich,

Nature Neuroscience · 2019 · 364 citations · 23 references

DOI

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23

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

Yaming Wang, Marina Cella, Kaitlin Mallinson et al. · Cell · 2015 · 1.8K citations · Full text

, , +17

Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

Rebecca Radde, Tristan Bolmont, Stephan A. Kaeser et al. · EMBO Reports · 2006 · 1K citations · Full text

, , +16

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

Yaming Wang, Tyler K. Ulland, Jason D. Ulrich et al. · The Journal of Experimental Medicine · 2016 · 882 citations · Full text

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TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

Peng Yuan, Carlo Condello, C. Dirk Keene et al. · Neuron · 2016 · 824 citations

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Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

Carlo Condello, Peng Yuan, Aaron Schain et al. · Nature Communications · 2015 · 746 citations · Full text

, , +17