Concepedia

Cheryl E. G. Leyns

CE

10

Publications

1.5K

Citations

10

H-Index

2017

Active since

Affiliations

Washington University in St. Louis(Current)

Hope Center for Neurological Disorders

Merck & Co., Inc., Rahway, NJ, USA (United States)

Institute on Aging

University of Pennsylvania

Cheryl E. G. Leyns is an author at Washington University in St. Louis specializing in medicine, cell biology, and neuroinflammation.

Top concepts

MedicineCell BiologyNeurologyImmunologyNeuroimmunologyNeurodegenerationNeuroinflammationSynaptic SignalingAlzheimer's DiseaseMolecular Signaling

Publications per year

2017–2024

10

Publications

10

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

Cheryl E. G. Leyns, Jason D. Ulrich, Mary Beth Finn et al. · Proceedings of the National Academy of Sciences · 2017 · 502 citations · Full text

Tau Pathology, Immunology, Cell Death +26

TREM2 function impedes tau seeding in neuritic plaques

Cheryl E. G. Leyns, Maud Gratuze, Sneha Narasimhan et al. · Nature Neuroscience · 2019 · 335 citations

Signal Transduction, Trem2 Function Impedes, Degenerative Pathology +3

Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration

Maud Gratuze, Cheryl E. G. Leyns, Andrew D. Sauerbeck et al. · Journal of Clinical Investigation · 2020 · 254 citations · Full text

Immunology, Pathology, Synaptic Signaling +22

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

Fan Liao, Aimin Li, Monica Xiong et al. · Journal of Clinical Investigation · 2018 · 177 citations · Full text

Targeting tauopathy with engineered tau-degrading intrabodies

Gilbert Gallardo, Connie Wong, Sara M. Ricardez Hernandez et al. · Molecular Neurodegeneration · 2019 · 62 citations · Full text

Rows per page

1–5 of 10