Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

Federica Sallusto, Marina Cella, Carlo Danieli, +1

The Journal of Experimental Medicine

Bacterial ProductsImmunologyImmune RegulationImmunologic MechanismAntigen Processing +20

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

Marina Cella, Doris Scheidegger, Kathrin Palmer-Lehmann, +3

The Journal of Experimental Medicine

Cd40-cd40l InteractionT-regulatory CellImmunologyCd4 T Cell ResponsesImmunotherapy +16

Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

Marina Cella, David Jarrossay, Fabio Facchetti, +4

Nature Medicine

InflammationCytokineImmune RegulationImmunologyImmunologic Mechanism +8

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

Yaming Wang, Marina Cella, Kaitlin Mallinson, +10

Cell

InflammationNeurodegenerative DiseasesAlzheimer's DiseaseDisease ModelMicroglial Response +10

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

Marina Cella, Anja Fuchs, William Vermi, +6

Nature

InflammationAutoimmune DiseaseMucosal ImmunologyInnate SourceInnate Immune System +9

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease

Tyler K. Ulland, Wilbur M. Song, Stanley Ching‐Cheng Huang, +16

Cell

Neurodegenerative DiseasesAlzheimer's DiseaseMedicineBrain-immune InteractionAlzheimer ’ +5

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

Leonid Gitlin, Winfried Barchet, Susan Gilfillan, +5

Proceedings of the National Academy of Sciences

Innate Immune SystemImmunologyImmunologic MechanismInnate ImmunityImmune System +14

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

Yingyue Zhou, Wilbur M. Song, Prabhakar S. Andhey, +22

Nature Medicine

Neurodegenerative DiseasesMolecular NeuroscienceAlzheimer's DiseaseSynaptic SignalingMedicine +11

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

Marina Cella, Anneke Engering, Valérie Pinet, +2

Nature

InflammationAutoimmune DiseaseImmunologyImmunologic MechanismAutoimmunity +9

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

Salvatore Valitutti, Sabina Müller, Marina Cella, +2

Nature

Signal TransductionAdaptive Immune SystemMany T-cell ReceptorsSerial TriggeringImmune Regulation +11