Concepedia

Tau Seeding

Tau seeding is a pathological process in which misfolded tau protein acts as a template to induce the aggregation of normal tau proteins, thereby propagating neurofibrillary pathology in a prion-like manner within neurodegenerative diseases.

194

Publications

20.8K

Citations

1.4K

Authors

387

Institutions

Publications per year

2017–2026

166

Parents

Publications

194

Tau protein liquid–liquid phase separation can initiate tau aggregation

Susanne Wegmann, Bahareh Eftekharzadeh, Katharina Tepper et al. · The EMBO Journal · 2018 · 1.1K citations · Full text

, , +17

Structures of filaments from Pick’s disease reveal a novel tau protein fold

Benjamin Falcon, Wenjuan Zhang, Alexey G. Murzin et al. · Nature · 2018 · 886 citations · Full text

, , +17

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

Brandon B. Holmes, Sarah L. DeVos, Najla Kfoury et al. · Proceedings of the National Academy of Sciences · 2013 · 849 citations · Full text

, , +17

Proteopathic tau seeding predicts tauopathy in vivo

Brandon B. Holmes, Jennifer L. Furman, Thomas E. Mahan et al. · Proceedings of the National Academy of Sciences · 2014 · 745 citations · Full text

, , +15

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

Hendrik Wesseling, Waltraud Mair, Mukesh Kumar et al. · Cell · 2020 · 710 citations · Full text

, , +17

1–5 of 194

Authors

1.4K

  1. MI
    Marc I. Diamond

    The University of Texas Southwestern Medical Center, United States

    25 publications · 4.8K citations

    22

    h-index

  2. BT
    Bradley T. Hyman

    Massachusetts General Hospital, United States

    11 publications · 2.8K citations

    11

    h-index

  3. VM
    Virginia M.‐Y. Lee

    University of Pennsylvania, United States

    10 publications · 2.7K citations

    10

    h-index

  4. DM
    David M. Holtzman

    Washington University in St. Louis, United States

    10 publications · 2.5K citations

    10

    h-index

  5. WA
    William A. McEwan

    MRC Laboratory of Molecular Biology, United Kingdom

    9 publications · 599 citations

    9

    h-index

1–5 of 1.4K

Institutions

387

  1. The University of Texas Southwestern Medical Center

    Dallas, United States

    18 h-index

    89 publications

    8.8K citations

  2. Washington University in St. Louis

    St Louis, United States

    17 h-index

    94 publications

    30.3K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    14 h-index

    63 publications

    4.6K citations

  4. Massachusetts General Hospital

    Boston, United States

    13 h-index

    102 publications

    24.3K citations

  5. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    12 h-index

    45 publications

    10.4K citations

  6. Harvard University

    Cambridge, United States

    12 h-index

    108 publications

    34.8K citations

  7. Inserm

    Paris, France

    12 h-index

    59 publications

    3.7K citations

  8. University of Pennsylvania

    Philadelphia, United States

    12 h-index

    70 publications

    20.2K citations

1–8 of 387

Venues

  1. Journal of Biological Chemistry

    JBC · 19 publications · 2.5K citations

    19

    h-index

  2. Acta Neuropathologica Communications

    18 publications · 810 citations

    17

    h-index

  3. Acta Neuropathologica

    15 publications · 2K citations

    14

    h-index

  4. Nature Communications

    7 publications · 691 citations

    7

    h-index

  5. Molecular Neurodegeneration

    MN · 6 publications · 447 citations

    6

    h-index

1–5