Concepedia

Publication | Open Access

Modulation of Target Antigen Density Improves CAR T-cell Functionality and Persistence

DOIFull Paper Access

173

Citations

37

References

2019

Year

Sneha Ramakrishna, Steven L. Highfill, Zachary Walsh, Sang M. Nguyen, Haiyan Lei, Jack F. Shern, Haiying Qin, Ira L. Kraft, Maryalice Stetler‐Stevenson, Constance M. Yuan,
Clinical Cancer Research

Abstract

We demonstrate that target antigen modulation is a promising strategy to improve CD22 CAR efficacy and remission durability in patients with leukemia and lymphoma.<i>See related commentary by Guedan and Delgado, p. 5188</i>.

References

YearCitations

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