Concepedia

Antigen Density Optimization

Antigen Density Optimization is a methodological approach in vaccine design that systematically adjusts the spatial arrangement and concentration of antigens on virus-like particles to maximize immunogenicity and host immune recognition.

22

Publications

1.5K

Citations

151

Authors

60

Institutions

Publications per year

2017–2026

7

Parents

Publications

22

Tuning the Antigen Density Requirement for CAR T-cell Activity

Robbie G. Majzner, Skyler P. Rietberg, Elena Sotillo et al. · Cancer Discovery · 2020 · 579 citations · Full text

, , +17

Enhanced Natural Killer Cell Binding and Activation by Low-Fucose IgG1 Antibody Results in Potent Antibody-Dependent Cellular Cytotoxicity Induction at Lower Antigen Density

Rinpei Niwa, Mikiko Sakurada, Yukari Kobayashi et al. · Clinical Cancer Research · 2005 · 189 citations

, , +16

Modulation of Target Antigen Density Improves CAR T-cell Functionality and Persistence

Sneha Ramakrishna, Steven L. Highfill, Zachary Walsh et al. · Clinical Cancer Research · 2019 · 175 citations · Full text

, , +17

Functional balance between T cell chimeric receptor density and tumor associated antigen density: CTL mediated cytolysis and lymphokine production

M. E. M. Weijtens, E. Hart, R. L. H. Bolhuis · Gene Therapy · 2000 · 95 citations

, , +16

The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer

Nan Li, Alex Quan, Dan Li et al. · Nature Communications · 2023 · 58 citations · Full text

, , +17

1–5 of 22

Authors

151

  1. RI
    Ronald I. Carr

    Jewish Hospital, United States

    2 publications · 41 citations

    2

    h-index

  2. SM
    Sang M. Nguyen

    National Cancer Institute, United States

    2 publications · 754 citations

    2

    h-index

  3. RL
    Robert L. Rubin

    Scripps Research Institute, United States

    2 publications · 41 citations

    2

    h-index

  4. MA
    Melissa A. Hardtke

    Jewish Hospital, United States

    2 publications · 41 citations

    2

    h-index

  5. MH
    Mitchell Ho

    National Cancer Institute, United States

    1 publications · 58 citations

    1

    h-index

1–5 of 151

Institutions

60

  1. University of Colorado Denver

    Denver, United States

    3 h-index

    8 publications

    473 citations

  2. Universitat de Barcelona

    Barcelona, Spain

    2 h-index

    2 publications

    67 citations

  3. National Cancer Institute

    Bethesda, United States

    2 h-index

    24 publications

    3.1K citations

  4. Jewish Hospital

    Cincinnati, United States

    2 h-index

    6 publications

    123 citations

  5. University of California, San Francisco

    San Francisco, United States

    2 h-index

    3 publications

    1.2K citations

  6. National Jewish Health

    Denver, United States

    2 h-index

    6 publications

    123 citations

  7. Universitat Autònoma de Barcelona

    Cerdanyola del Vallès, Spain

    1 h-index

    4 publications

    136 citations

  8. Institute of Microbiology

    Beijing, China

    1 h-index

    6 publications

    120 citations

1–8 of 60

Venues

  1. Journal of Immunological Methods

    5 publications · 123 citations

    5

    h-index

  2. Clinical Cancer Research

    2 publications · 364 citations

    2

    h-index

  3. Protein Expression and Purification

    1 publications · 20 citations

    1

    h-index

  4. Cancer Discovery

    1 publications · 579 citations

    1

    h-index

  5. Nature

    1 publications · 39 citations

    1

    h-index

1–5