Enhanced Natural Killer Cell Binding and Activation by Low-Fucose IgG1 Antibody Results in Potent Antibody-Dependent Cellular Cytotoxicity Induction at Lower Antigen Density - Concepedia

Concepedia

Publication | Closed Access

Enhanced Natural Killer Cell Binding and Activation by Low-Fucose IgG1 Antibody Results in Potent Antibody-Dependent Cellular Cytotoxicity Induction at Lower Antigen Density

188

Citations

42

References

2005

Year

Rinpei Niwa, Mikiko Sakurada, Yukari Kobayashi, Aya Uehara, Kouji Matsushima, Ryuzo Ueda, Kazuyasu Nakamura, Kenya Shitara

Clinical Cancer Research

Abstract

Our data showed that fucose removal from IgG1 could reduce the antigen amount required for ADCC induction via efficient recruitment and activation of NK cells.

References

	Year	Citations

Page 1