Concepedia

Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets

Raphael Clynes, Terri L. Towers, Leonard G. Presta, Jeffrey V. Ravetch

Nature Medicine · 2000 · 2.7K citations · 17 references

DOI

Concepts

References

17

Humanization of an anti-p185HER2 antibody for human cancer therapy.

Paul Carter, Leonard G. Presta, C Gorman et al. · Proceedings of the National Academy of Sciences · 1992 · 1.9K citations

, , +16

Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment.

Mark D. Pegram, A. Lipton, Daniel F. Hayes et al. · Journal of Clinical Oncology · 1998 · 1.1K citations

, , +17

Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts.

José Baselga, Larry Norton, Joan Albanell et al. · PubMed · 1998 · 1K citations

, , +15

FcR γ chain deletion results in pleiotrophic effector cell defects

Toshiyuki Takai, Min Li, Diana L. Sylvestre et al. · Cell · 1994 · 968 citations

, , +3

Augmented humoral and anaphylactic responses in FcγRII-deficient mice

Toshiyuki Takai, Masao Ono, Masaki Hikida et al. · Nature · 1996 · 828 citations

, , +12