Concepedia

Fc-dependent Cytotoxicity Optimization

Fc-Dependent Cytotoxicity Optimization is a methodological framework in immunotherapeutic protein engineering that enhances the efficacy of antibody-mediated immune responses by selectively modulating the Fc region’s interaction with Fcγ receptors to maximize target cell lysis through natural killer cell or macrophage activation.

8

Publications

3K

Citations

60

Authors

23

Institutions

Publications per year

2017–2026

1

Parents

Publications

8

Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets

Raphael Clynes, Terri L. Towers, Leonard G. Presta et al. · Nature Medicine · 2000 · 2.7K citations

, , +15

A novel Fc-engineered monoclonal antibody to CD37 with enhanced ADCC and high proapoptotic activity for treatment of B-cell malignancies

Karl‐Heinz Heider, Kerstin Kiefer, Thorsten Zenz et al. · Blood · 2011 · 103 citations · Full text

, , +15

Immunoglobulin Fc Domain Fusion to TRAIL Significantly Prolongs Its Plasma Half-Life and Enhances Its Antitumor Activity

Haizhen Wang, Jennifer S. Davis, Xiangwei Wu · Molecular Cancer Therapeutics · 2014 · 53 citations

, , +16

The development and kinetics of functional antibody-dependent cell-mediated cytotoxicity (ADCC) to SARS-CoV-2 spike protein

Xuemin Chen, Christina A. Rostad, Larry J. Anderson et al. · Virology · 2021 · 40 citations · Full text

, , +9

Fc-Optimized NKG2D–Fc Constructs Induce NK Cell Antibody-Dependent Cellular Cytotoxicity against Breast Cancer Cells Independently of HER2/neu Expression Status

Stefanie Raab, Julia Steinbacher, Benjamin Joachim Schmiedel et al. · The Journal of Immunology · 2014 · 33 citations · Full text

, , +16

1–5 of 8

Authors

60

  1. YS
    Yoshitaka Shirasago

    National Institute of Infectious Diseases, Japan

    1 publications · 19 citations

    1

    h-index

  2. NR
    Nadine Rouphael

    Emory University, United States

    1 publications · 40 citations

    1

    h-index

  3. CA
    Christina A. Rostad

    Emory University, United States

    1 publications · 40 citations

    1

    h-index

  4. JF
    Jiannan Feng

    Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences

    1 publications · 18 citations

    1

    h-index

  5. RS
    Rui Sun

    University of Science and Technology of China, China

    1 publications · 11 citations

    1

    h-index

1–5 of 60

Institutions

23

  1. University of Tübingen

    Tübingen, Germany

    1 h-index

    7 publications

    231 citations

  2. The University of Texas MD Anderson Cancer Center

    Houston, United States

    1 h-index

    3 publications

    159 citations

  3. Xiamen University

    Xiamen, China

    1 h-index

    1 publications

    11 citations

  4. National Institutes of Health

    Bethesda, United States

    1 h-index

    10 publications

    190 citations

  5. Children's Healthcare of Atlanta

    Atlanta, United States

    1 h-index

    5 publications

    200 citations

  6. Heidelberg University

    Heidelberg, Germany

    1 h-index

    5 publications

    165 citations

  7. Goethe-Institute United Kingdom

    London, United Kingdom

    1 h-index

    1 publications

    33 citations

  8. The University of Osaka

    Osaka, Japan

    1 h-index

    10 publications

    190 citations

1–8 of 23

Venues

  1. Blood

    1 publications · 103 citations

    1

    h-index

  2. Molecular Immunology

    1 publications · 18 citations

    1

    h-index

  3. Nature Medicine

    1 publications · 2.7K citations

    1

    h-index

  4. 1

    h-index

  5. Journal of Biological Chemistry

    JBC · 1 publications · 11 citations

    1

    h-index

1–5