Establishment of <i>FUT8</i> knockout Chinese hamster ovary cells: An ideal host cell line for producing completely defucosylated antibodies with enhanced antibody‐dependent cellular cytotoxicity

Naoko Yamane‐Ohnuki, Satoko Kinoshita, Miho Inoue‐Urakubo, +9

Biotechnology and Bioengineering

AllergyAutoimmune DiseaseMedicineImmunologyCell Lines +13

Defucosylated Chimeric Anti-CC Chemokine Receptor 4 IgG1 with Enhanced Antibody-Dependent Cellular Cytotoxicity Shows Potent Therapeutic Activity to T-Cell Leukemia and Lymphoma

Rinpei Niwa, Emi Shoji-Hosaka, Mikiko Sakurada, +7

Cancer Research

Km2760 FunctionsIgg1 Antibody Km2760Cancer ImmunosurveillanceMedicineImmunology +11

IgG subclass-independent improvement of antibody-dependent cellular cytotoxicity by fucose removal from Asn297-linked oligosaccharides

Rinpei Niwa, Akito Natsume, Aya Uehara, +5

Journal of Immunological Methods

Enhancement of the Antibody-Dependent Cellular Cytotoxicity of Low-Fucose IgG1 Is Independent of FcγRIIIa Functional Polymorphism

Rinpei Niwa, Shigeki Hatanaka, Emi Shoji-Hosaka, +6

Clinical Cancer Research

Enhanced Natural Killer Cell Binding and Activation by Low-Fucose IgG1 Antibody Results in Potent Antibody-Dependent Cellular Cytotoxicity Induction at Lower Antigen Density

Rinpei Niwa, Mikiko Sakurada, Yukari Kobayashi, +5

Clinical Cancer Research

Engineered Antibodies of IgG1/IgG3 Mixed Isotype with Enhanced Cytotoxic Activities

Akito Natsume, Mika In, Hiroyuki Takamura, +8

Cancer Research

Immunocytochemical TechniqueEngineeringImmunologyImmunodominanceAntigen Processing +18

Engineering Chinese hamster ovary cells to maximize effector function of produced antibodies using FUT8 siRNA

Katsuhiro Mori, Reiko Kuni‐Kamochi, Naoko Yamane‐Ohnuki, +9

Biotechnology and Bioengineering

Improving effector functions of antibodies for cancer treatment: Enhancing ADCC and CDC.

Akito Natsume, Rinpei Niwa, Mitsuo Satoh

PubMed

ImmunologyImmunotherapeuticsImmune Cell TherapyImmunotherapyTumor Biology +22

A Nonfucosylated Anti-HER2 Antibody Augments Antibody-Dependent Cellular Cytotoxicity in Breast Cancer Patients

Eiji Suzuki, Rinpei Niwa, Shigehira Saji, +8

Clinical Cancer Research

Non-fucosylated therapeutic antibodies: the next generation of therapeutic antibodies

Katsuhiro Mori, Shigeru Iida, Naoko Yamane‐Ohnuki, +10

Cytotechnology

Autoimmune DiseaseImmunologyAntibody ScreeningAutoimmunityImmunochemistry +5