Concepedia

T Cell Activation

T Cell Activation is a cellular immune process in adaptive immunity whereby a naïve or resting T lymphocyte, upon recognizing a specific peptide–MHC complex on an antigen-presenting cell together with appropriate co-stimulatory signals, initiates intracellular signaling cascades that induce its clonal expansion and differentiation into effector and memory T cells.

48.8K

Publications

4M

Citations

148.6K

Authors

9.9K

Institutions

Publications per year

2017–2026

6.6K

Parents

Children

Publications

48.8K

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

Timothy R. Mosmann, Holly Cherwinski, M W Bond et al. · The Journal of Immunology · 1986 · 7.5K citations

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Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Gordon J. Freeman, Andrew J. Long, Yoshiko Iwai et al. · The Journal of Experimental Medicine · 2000 · 5.2K citations · Full text

, , +17

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

Federica Sallusto, Antonio Lanzavecchia · The Journal of Experimental Medicine · 1994 · 5.2K citations · Full text

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Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

Alba Grifoni, Daniela Weiskopf, Sydney I. Ramirez et al. · Cell · 2020 · 4K citations · Full text

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Restoring function in exhausted CD8 T cells during chronic viral infection

Daniel L. Barber, E. John Wherry, David Masopust et al. · Nature · 2005 · 4K citations

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1–5 of 48.8K

Authors

148.6K

  1. MM
    Mark M. Davis

    Stanford University, United States

    141 publications · 35.7K citations

    90

    h-index

  2. CH
    Carl H. June

    University of Pennsylvania, United States

    174 publications · 38.1K citations

    89

    h-index

  3. BD
    Bruce D. Walker

    Massachusetts General Hospital, United States

    166 publications · 28.8K citations

    84

    h-index

  4. AS
    Alessandro Sette

    La Jolla Institute for Immunology, United States

    188 publications · 30.2K citations

    79

    h-index

  5. DA
    David A. Price

    Cardiff University, United Kingdom

    150 publications · 21.5K citations

    72

    h-index

1–5 of 148.6K

Institutions

9.9K

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    272 h-index

    1.4K publications

    273.4K citations

  2. National Institutes of Health

    Bethesda, United States

    261 h-index

    2.1K publications

    280.3K citations

  3. Harvard University

    Cambridge, United States

    257 h-index

    2.1K publications

    278.2K citations

  4. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    200 h-index

    1.1K publications

    161.1K citations

  5. National Cancer Institute

    Bethesda, United States

    185 h-index

    1.1K publications

    141.8K citations

  6. Brigham and Women's Hospital

    Boston, United States

    182 h-index

    818 publications

    129.9K citations

  7. Dana-Farber Cancer Institute

    Boston, United States

    180 h-index

    982 publications

    136.4K citations

  8. Inserm

    Paris, France

    176 h-index

    1.9K publications

    146.3K citations

1–8 of 9.9K

Venues

  1. The Journal of Experimental Medicine

    2.2K publications · 384.3K citations

    306

    h-index

  2. The Journal of Immunology

    JI · 8.3K publications · 653.7K citations

    281

    h-index

  3. Nature

    724 publications · 232.1K citations

    262

    h-index

  4. Immunity

    764 publications · 199K citations

    253

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 1.5K publications · 204.2K citations

    229

    h-index

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