Concepedia

Lck Activation

Lck Activation is a biochemical signaling event, as a specific instance of kinase activation, characterized by the phosphorylation-induced conformational change and catalytic activation of the lymphocyte-specific protein tyrosine kinase (Lck) that initiates the downstream signaling cascade in T cell receptor-mediated T cell activation.

770

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62.6K

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3.5K

Authors

832

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Publications per year

2017–2026

69

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Publications

770

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

Jeffrey H. Hanke, Joseph P. Gardner, Robert L. Dow et al. · Journal of Biological Chemistry · 1996 · 2K citations · Full text

, , +17

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

André Veillette, Michael A. Bookman, Eva Horak et al. · Cell · 1988 · 1.4K citations

, , +14

Role of Translocation in the Activation and Function of Protein Kinase B

Mirjana Andjelković, Dario R. Alessi, Roger Meier et al. · Journal of Biological Chemistry · 1997 · 1.1K citations · Full text

, , +12

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

David B. Straus · Cell · 1992 · 1K citations

, , +16

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

Antonella Viola, Susanne Schroeder, Yoichi Sakakibara et al. · Science · 1999 · 941 citations

, , +17

1–5 of 770

Authors

3.5K

  1. AV
    André Veillette

    McGill University, Canada

    31 publications · 3.5K citations

    25

    h-index

  2. TM
    Tomas Mustelin

    Sanford Burnham Prebys Medical Discovery Institute, United States

    22 publications · 2.2K citations

    21

    h-index

  3. RM
    Roger M. Perlmutter

    Howard Hughes Medical Institute, United States

    19 publications · 2.8K citations

    19

    h-index

  4. BM
    Bartholomew M. Sefton

    Salk Institute for Biological Studies, United States

    20 publications · 1.8K citations

    17

    h-index

  5. AW
    Arthur Weiss

    Howard Hughes Medical Institute, United States

    14 publications · 2.7K citations

    14

    h-index

1–5 of 3.5K

Institutions

832

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    36 h-index

    143 publications

    21.8K citations

  2. Harvard University

    Cambridge, United States

    31 h-index

    139 publications

    11.8K citations

  3. Inserm

    Paris, France

    28 h-index

    178 publications

    10.6K citations

  4. Dana-Farber Cancer Institute

    Boston, United States

    27 h-index

    114 publications

    10.6K citations

  5. La Jolla Institute for Immunology

    San Diego, United States

    23 h-index

    107 publications

    8.1K citations

  6. National Institutes of Health

    Bethesda, United States

    22 h-index

    89 publications

    10.2K citations

  7. National Cancer Institute

    Bethesda, United States

    22 h-index

    87 publications

    12.9K citations

  8. Salk Institute for Biological Studies

    La Jolla, United States

    19 h-index

    53 publications

    4.2K citations

1–8 of 832

Venues

  1. Journal of Biological Chemistry

    JBC · 99 publications · 10.1K citations

    50

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  2. The Journal of Immunology

    JI · 103 publications · 4.7K citations

    44

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  3. Molecular and Cellular Biology

    MCB · 52 publications · 4.6K citations

    36

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  4. Proceedings of the National Academy of Sciences

    PNAS · 36 publications · 5.4K citations

    31

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  5. The Journal of Experimental Medicine

    33 publications · 4K citations

    30

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