Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

Jeffrey H. Hanke, Joseph P. Gardner, Robert L. Dow, +5

Journal of Biological Chemistry

Total synthesis of the polyether antibiotic ionomycin

David A. Evans, Robert L. Dow, Thomas L. Shih, +2

Journal of the American Chemical Society

Bioorganic ChemistryAntibiotic AdjuvantAltmetric Attention ScoreAntimicrobial ChemotherapyPharmaceutical Chemistry +16

Aldol addition reactions of chiral crotonate imides

David A. Evans, Eric B. Sjogren, Javier Bartrolí, +1

Tetrahedron Letters

Chiral Crotonate ImidesStereoselective SynthesisPharmacologyAsymmetric CatalysisEnantioselective Synthesis

Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1

Robert L. Dow, Jiancheng Li, Michael P. Pence, +13

ACS Medicinal Chemistry Letters

Pharmaceutical SciencePharmacotherapyPharmaceutical ChemistryInsulin SignalingMetabolic Syndrome +14

Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TRβ subtype-selective thyromimetics

Robert L. Dow, Steven R. Schneider, Ernest S. Paight, +19

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryNovel SeriesBiochemistryMedicine +5

Hydroxyl-directed hydrogenation of homoallylic alcohols. Effects of achiral and chiral rhodium catalysts on 1,3 stereocontrol.

David A. Evans, M. M. MORRISSEY, Robert L. Dow

Tetrahedron Letters

Asymmetric CatalysisChemical EngineeringEngineeringChiral Rhodium CatalystsOrganic Chemistry +8

Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9<i>H</i>-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist

David A. Griffith, John R. Hadcock, Shawn C. Black, +9

Journal of Medicinal Chemistry

Benzyloxazolidine-2,4-diones as potent hypoglycemic agents

Robert L. Dow, Bruce M. Bechle, Thomas T. Chou, +3

Journal of Medicinal Chemistry

Metabolic SyndromeBenzofuran Structural ElementBiochemistryVivo PotencyPhysiology +10

Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure

David A. Griffith, Robert L. Dow, Kim Huard, +20

Journal of Medicinal Chemistry

Medicinal ChemistryChromanone Lead StructureBioorganic ChemistryPharmaceutical ChemistryBiochemistry +12

Discovery of 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2<i>H</i>-pyrazolo[3,4-<i>f</i>][1,4]oxazepin-8(5<i>H</i>)-one (PF-514273), a Novel, Bicyclic Lactam-Based Cannabinoid-1 Receptor Antagonist for the Treatment of Obesity

Robert L. Dow, Philip A. Carpino, John R. Hadcock, +9

Journal of Medicinal Chemistry

Drug TargetReceptor AntagonistsFood IntakePharmacotherapyCannabinoid Pharmacology +14