Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Gordon J. Freeman, Andrew J. Long, Yoshiko Iwai, +16

The Journal of Experimental Medicine

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

Yoshiko Iwai, Masayoshi Ishida, Yoshimasa Tanaka, +3

Proceedings of the National Academy of Sciences

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

Yvette Latchman, Clive R. Wood, Tatyana Chernova, +18

Nature Immunology

Cancer ImmunosurveillanceSignal TransductionImmunologySecond LigandImmunologic Mechanism +6

PD-L1/B7H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor (TCR) Transgenic CD8+ T Cells

Christian U. Blank, Ian E. Brown, Amy Peterson, +4

Cancer Research

PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells

Yoshiko Iwai

International Immunology

Enhanced RecruitmentImmunologyImmune RegulationPathologyImmunoediting +17

PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver

Yoshiko Iwai, Seigo Terawaki, Masaya Ikegawa, +2

The Journal of Experimental Medicine

Effector PhaseT-regulatory CellViral ImmunityImmunologyPathology +20

Blockade of Programmed Death-1 Engagement Accelerates Graft-Versus-Host Disease Lethality by an IFN-γ-Dependent Mechanism

Bruce R. Blazar, Beatriz M. Carreno, Angela Panoskaltsis‐Mortari, +5

The Journal of Immunology

Cell TherapyGvhd EnhancementT-regulatory CellApoptosisImmunology +22

Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues

Masayoshi Ishida, Yoshiko Iwai, Yoshimasa Tanaka, +4

Immunology Letters

Autoimmune DiseaseDifferential ExpressionInhibitory Receptor Pd-1Immune RegulationImmunology +9

IκBζ regulates TH17 development by cooperating with ROR nuclear receptors

Kazuo Okamoto, Yoshiko Iwai, Masatsugu Oh‐hora, +8

Nature

Th17 DevelopmentTranscriptional RegulationSignal TransductionSignaling PathwayCell Regulation +4

Selective delivery of β cell antigen to dendritic cells <i>in vivo</i> leads to deletion and tolerance of autoreactive CD8 ⁺ T cells in NOD mice

Arunika Mukhopadhaya, Tadashi Hanafusa, Irene Jarchum, +6

Proceedings of the National Academy of Sciences

Immune RegulationImmunologyImmunodominanceAntigen ProcessingCd4 T Cell Responses +18