T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

Daniel W Lee, James N. Kochenderfer, Maryalice Stetler‐Stevenson, +15

The Lancet

T CellsT-regulatory CellImmunologyHematologyAutoimmunity +7

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

Adrienne H. Long, Waleed Haso, Jack F. Shern, +12

Nature Medicine

Autoimmune DiseaseTonic SignalingImmunologyAntigen ProcessingAutoimmunity +10

CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy

Terry J. Fry, Nirali N. Shah, Rimas J. Orentas, +21

Nature Medicine

AllergyAutoimmune DiseaseCd19-targeted Car ImmunotherapyAdaptive Immune SystemT-regulatory Cell +7

Convergence of Acquired Mutations and Alternative Splicing of <i>CD19</i> Enables Resistance to CART-19 Immunotherapy

Elena Sotillo, David M. Barrett, Kathryn L. Black, +27

Cancer Discovery

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

Marco Ruella, Jun Xu, David M. Barrett, +23

Nature Medicine

Autoimmune DiseaseImmunologyAntigen ProcessingAutoimmunityAdult T-cell Leukemia-lymphoma +3

CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial

Jay Y. Spiegel, Shabnum Patel, Lori Muffly, +46

Nature Medicine

Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

Claude Sportès, Frances T. Hakim, Sarfraz Memon, +17

The Journal of Experimental Medicine

IL-7 Administration to Humans Leads to Expansion of CD8+ and CD4+ Cells but a Relative Decrease of CD4+ T-Regulatory Cells

Steven A. Rosenberg, Claude Sportès, Mojgan Ahmadzadeh, +10

Journal of Immunotherapy

Il-7 AdministrationCd4+ CellsT-regulatory CellImmune RegulationImmunology +16

CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity

Elad Jacoby, Sang M. Nguyen, Thomas J. Fountaine, +15

Nature Communications

CD4/CD8 T-Cell Selection Affects Chimeric Antigen Receptor (CAR) T-Cell Potency and Toxicity: Updated Results From a Phase I Anti-CD22 CAR T-Cell Trial

Nirali N. Shah, Steven L. Highfill, Haneen Shalabi, +22

Journal of Clinical Oncology