Jack F. Shern

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

Adrienne H. Long, Waleed Haso, Jack F. Shern et al. · Nature Medicine · 2015 · 1.7K citations · Full text

Autoimmune Disease, Tonic Signaling, Immunology +12

CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy

Terry J. Fry, Nirali N. Shah, Rimas J. Orentas et al. · Nature Medicine · 2017 · 1.3K citations · Full text

Allergy, Autoimmune Disease, Cd19-targeted Car Immunotherapy +9

Comprehensive Genomic Analysis of Rhabdomyosarcoma Reveals a Landscape of Alterations Affecting a Common Genetic Axis in Fusion-Positive and Fusion-Negative Tumors

Jack F. Shern, Li Chen, Juliann Chmielecki et al. · Cancer Discovery · 2014 · 759 citations · Full text

The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent STAG2 Mutation

Andrew S. Brohl, David A. Solomon, Wendy Chang et al. · PLoS Genetics · 2014 · 440 citations · Full text

Ewing Sarcoma, Engineering, Somatic Variant +15

CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity

Elad Jacoby, Sang M. Nguyen, Thomas J. Fountaine et al. · Nature Communications · 2016 · 411 citations · Full text