Cd22-mediated Regulation

CD22-Mediated Regulation is a molecular inhibitory mechanism within B cell receptor signaling that specifically attenuates activation signals through the recruitment of phosphatases by the transmembrane glycoprotein CD22 upon ligand engagement.

177

Publications

16.1K

Citations

822

Authors

287

Institutions

Publications per year

2017–2026

Parents

B Cell Receptor Signaling

Publications

177

CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy

Terry J. Fry, Nirali N. Shah, Rimas J. Orentas et al. · Nature Medicine · 2017 · 1.3K citations

Life Sciences, Immunology, Oncology +14

Anti-CD22–chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia

Waleed Haso, Daniel W. Lee, Nirali N. Shah et al. · Blood · 2012 · 583 citations · Full text

Medicine, Immunology, Oncology +9

A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP

Gina M. Doody, Louis B. Justement, Catherine C. Delibrias et al. · Science · 1995 · 546 citations

Life Sciences, Immunology, Molecular Biology +16

Hyperresponsive B Cells in CD22-Deficient Mice

Theresa L. O’Keefe, Gareth T. Williams, Sarah L. Davies et al. · Science · 1996 · 531 citations

Life Sciences, Cell Biology, Immunology +17

CD22 is a negative regulator of B-cell receptor signalling

Lars Nitschke, Rita Carsetti, Bettina Ocker et al. · Current Biology · 1997 · 441 citations · Full text

Life Sciences, Immunology, Molecular Biology +14

1–5 of 177

Authors

822

TF
Thomas F. Tedder
Duke Medical Center, United States
20 publications · 1.7K citations
19
h-index
LN
Lars Nitschke
Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany
24 publications · 1.7K citations
18
h-index
JC
James C. Paulson
Scripps Research Institute, United States
17 publications · 1.6K citations
16
h-index
MF
Manabu Fujimoto
Kanazawa University, Japan
12 publications · 779 citations
12
h-index
EA
Edward A. Clark
University of Washington, United States
12 publications · 1.4K citations
12
h-index

1–5 of 822

Institutions

287

1–8 of 287

Venues

The Journal of Immunology
JI · 31 publications · 1.6K citations
23
h-index
Blood
14 publications · 1.5K citations
13
h-index
Journal of Biological Chemistry
JBC · 13 publications · 1.1K citations
13
h-index
European Journal of Immunology
EJI · 13 publications · 812 citations
12
h-index
Proceedings of the National Academy of Sciences
PNAS · 9 publications · 1.2K citations
9
h-index

1–5