Lars Nitschke

CD22 is a negative regulator of B-cell receptor signalling

Lars Nitschke, Rita Carsetti, Bettina Ocker et al. · Current Biology · 1997 · 432 citations · Full text

Immunology, B-cell Receptor, Immunologic Mechanism +5

B Cell-Specific Deletion of Protein-Tyrosine Phosphatase Shp1 Promotes B-1a Cell Development and Causes Systemic Autoimmunity

Lily Pao, Kong‐Peng Lam, Joel Henderson et al. · Immunity · 2007 · 249 citations · Full text

Signal Transduction, Autoimmune Disease, Autoantibody Production +13

Siglec-G is a B1 cell–inhibitory receptor that controls expansion and calcium signaling of the B1 cell population

Anja Hoffmann, Sheena C. Kerr, Julia Jellusova et al. · Nature Immunology · 2007 · 190 citations

Signal Transduction, Signaling Pathway, Cell Regulation +10

The murine inhibitory receptor mSiglec‐E is expressed broadly on cells of the innate immune system whereas mSiglec‐F is restricted to eosinophils

Jiquan Q. Zhang, Björn Biedermann, Lars Nitschke et al. · European Journal of Immunology · 2004 · 189 citations

The Ligand-binding Domain of CD22 Is Needed for Inhibition of the B Cell Receptor Signal, as Demonstrated by a Novel Human CD22-specific Inhibitor Compound

Judith Gerlach, Reinhard Brossmer, Claus-Peter Danzer et al. · The Journal of Experimental Medicine · 2002 · 178 citations · Full text

Immunology, Immunologic Mechanism, Immunotherapy +16