Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens

Multiplex Genome Engineering Using CRISPR/Cas Systems

Le Cong, F. Ann Ran, David Cox et al. · Science · 2013 · 15.4K citations

Single Crispr Array, Engineering, Short Rnas +12

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

John G. Doench, Nicolò Fusi, Meagan E. Sullender et al. · Nature Biotechnology · 2016 · 4.7K citations · Full text

Systems Biology, Off-target Effect, Natural Sciences +10

Simultaneous epitope and transcriptome measurement in single cells

Marlon Stoeckius, Christoph Hafemeister, William Stephenson et al. · Nature Methods · 2017 · 3.1K citations · Full text

Systems Biology, Single Cell Sequencing, Medicine +8

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

Jesse M. Zaretsky, Ángel García-Díaz, Daniel Sanghoon Shin et al. · New England Journal of Medicine · 2016 · 3.1K citations · Full text

An immunogenic personal neoantigen vaccine for patients with melanoma

Patrick A. Ott, Zhuting Hu, Derin B. Keskin et al. · Nature · 2017 · 2.8K citations · Full text

Vaccination, Tumor Immunology, Melanoma +5