β-Catenin Activation Promotes Immune Escape and Resistance to Anti–PD-1 Therapy in Hepatocellular Carcinoma

Marina Ruiz de Galarreta, Erin Bresnahan, Pedro Molina-Sánchez, +20

Cancer Discovery

Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells

María Casanova-Acebes, Erica Dalla, Andrew M. Leader, +24

Nature

InflammationMedicineImmunologyTumor ImmunityPathology +8

Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination

Linda Hammerich, Thomas U. Marron, Ranjan Upadhyay, +12

Nature Medicine

VaccinationTumor ImmunologyCancer ImmunosurveillanceMedicineSitu Vaccination +9

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

Ricardo Grieshaber‐Bouyer, Felix A. Radtke, Pierre Cunin, +88

Nature Communications

Spatial CRISPR genomics identifies regulators of the tumor microenvironment

Maxime Dhainaut, Samuel A. Rose, Güray Aktürk, +18

Cell

Tumor BiologyGene EditingCrisprGenome EditingSpatial Crispr Genomics +4

Quiescent Tissue Stem Cells Evade Immune Surveillance

Judith Agudo, Eun Sook Park, Samuel A. Rose, +8

Immunity

MedicineAdult Stem CellImmunologyStem Cell ResearchImmunotherapy +2

Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes

Evgeny Kiner, Elijah Willie, Brinda Vijaykumar, +95

Nature Immunology

Mucosal ImmunologyTh ArchetypesT-regulatory CellPathogenesisImmunology +5

Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens

Aleksandra Wroblewska, Maxime Dhainaut, Benjamin Ben-Zvi, +8

Cell

EngineeringMedicineGenetic EngineeringSynthetic BiologyGene Editing +4

Guidelines for Optimized Gene Knockout Using CRISPR/Cas9

Claude Van Campenhout, Pauline Cabochette, Anne-Clémence Veillard, +7

BioTechniques

Crispr/cas9 Genome-targeting EfficiencyCrispr/cas9 Genome-editing ExperimentsEngineeringGenome SurgeryOff-target Effect +13

A microRNA expression and regulatory element activity atlas of the mouse immune system

Samuel A. Rose, Aleksandra Wroblewska, Maxime Dhainaut, +93

Nature Immunology

Systems BiologyMouse Immune SystemMicrorna ExpressionEngineeringImmunology +9