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Control of chronic lymphocytic leukemia development by clonally-expanded CD8+ T-cells that undergo functional exhaustion in secondary lymphoid tissues

Lymphoid NeoplasiaDevelopmental BiologyLymphocyte DevelopmentMalignant Blood DisorderImmunologyHematologyAutoimmunityAdult T-cell Leukemia-lymphomaMedicineCell BiologyUndergo Functional ExhaustionClonally-expanded Cd8+ T-cellsSecondary Lymphoid Tissues