Concepedia

Functional Exhaustion

Functional Exhaustion is a pathological state of Tumor-Infiltrating Lymphocytes characterized by the progressive and hierarchical loss of effector functions, sustained expression of inhibitory receptors, and transcriptional reprogramming that impairs their ability to eliminate cancer cells.

196

Publications

20.4K

Citations

1.7K

Authors

564

Institutions

Publications per year

2017–2026

106

Variants

T Cell Exhaustion

Parents

Publications

196

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

Bo Diao, Chenhui Wang, Yingjun Tan et al. · Frontiers in Immunology · 2020 · 2.5K citations · Full text

, , +17

Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

E. John Wherry, Joseph N. Blattman, Kaja Murali‐Krishna et al. · Journal of Virology · 2003 · 1.6K citations

, , +17

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8 <sup>+</sup> T cell exhaustion

Hyungseok Seo, Joyce Chen, Edahí González‐Avalos et al. · Proceedings of the National Academy of Sciences · 2019 · 769 citations · Full text

, , +17

Cancer-related fatigue: ESMO Clinical Practice Guidelines for diagnosis and treatment

Alessandra Fabi, Ravi Bhargava, Sonia Fatigoni et al. · Annals of Oncology · 2020 · 551 citations · Full text

, , +14

Reduction and Functional Exhaustion of T Cells in Patients with Coronavirus Disease 2019 (COVID-19)

Bo Diao, Chenhui Wang, Yingjun Tan et al. · medRxiv · 2020 · 365 citations · Full text

, , +17

1–5 of 196

Authors

1.7K

  1. SH
    Sang‐Jun Ha

    Yonsei University, South Korea

    4 publications · 526 citations

    4

    h-index

  2. SK
    Satoru Konnai

    Hokkaido University, Japan

    3 publications · 132 citations

    3

    h-index

  3. ZT
    Zhigang Tian

    University of Science and Technology of China, China

    3 publications · 398 citations

    3

    h-index

  4. AM
    Arnaud Marchant

    Université Libre de Bruxelles, Belgium

    3 publications · 157 citations

    3

    h-index

  5. KO
    Kazuhiko Ohashi

    Hokkaido University, Japan

    3 publications · 132 citations

    3

    h-index

1–5 of 1.7K

Institutions

564

  1. University of Pittsburgh

    Pittsburgh, United States

    7 h-index

    48 publications

    6.4K citations

  2. University of California San Diego

    San Diego, United States

    6 h-index

    27 publications

    9.7K citations

  3. Heidelberg University

    Heidelberg, Germany

    6 h-index

    23 publications

    5.1K citations

  4. Harvard University

    Cambridge, United States

    6 h-index

    12 publications

    1.1K citations

  5. Emory University

    Atlanta, United States

    5 h-index

    29 publications

    11.8K citations

  6. Inserm

    Paris, France

    5 h-index

    38 publications

    5.5K citations

  7. National Institutes of Health

    Bethesda, United States

    5 h-index

    31 publications

    4.8K citations

  8. University Hospital Heidelberg

    Heidelberg, Germany

    5 h-index

    9 publications

    2.3K citations

1–8 of 564

Venues

  1. Frontiers in Immunology

    13 publications · 3.5K citations

    12

    h-index

  2. The Journal of Immunology

    JI · 9 publications · 1.2K citations

    9

    h-index

  3. Journal of Virology

    JVI · 7 publications · 1.8K citations

    7

    h-index

  4. European Journal of Immunology

    EJI · 6 publications · 298 citations

    6

    h-index

  5. Journal of Clinical Investigation

    JCI · 6 publications · 718 citations

    6

    h-index

1–5