Concepedia

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Kristen E. Pauken, Morgan A. Sammons, Pamela M. Odorizzi, Sasikanth Manne, Jernej Godec, Omar Khan, Adam Drake, Zeyu Chen, Debattama R. Sen, Makoto Kurachi,

Science · 2016 · 1.3K citations · 30 references

DOI

Concepts

Abstract

epigenetic landscape. These data indicate that epigenetic fate inflexibility may limit current immunotherapies.

References

30

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

Sven Heinz, Christopher Benner, Nathanael J. Spann et al. · Molecular Cell · 2010 · 14.6K citations · Full text

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Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

Jason D. Buenrostro, Paul G. Giresi, Lisa C. Zaba et al. · Nature Methods · 2013 · 7K citations · Full text

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Restoring function in exhausted CD8 T cells during chronic viral infection

Daniel L. Barber, E. John Wherry, David Masopust et al. · Nature · 2005 · 4K citations

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Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

Se Jin Im, Masao Hashimoto, Michael Y. Gerner et al. · Nature · 2016 · 2.1K citations · Full text

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Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

Matthew M. Gubin, Xiuli Zhang, Heiko Schuster et al. · Nature · 2014 · 2K citations · Full text

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