Kristen E. Pauken

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

Christina Twyman-Saint Victor, Andrew J. Rech, Amit Maity et al. · Nature · 2015 · 2.3K citations · Full text

Cancer Immunosurveillance, Medicine, Immunology +9

T-cell invigoration to tumour burden ratio associated with anti-PD-1 response

Alexander C. Huang, Michael A. Postow, Robert J. Orlowski et al. · Nature · 2017 · 1.6K citations · Full text

Burden Ratio, Cancer Immunosurveillance, Medicine +8

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Kristen E. Pauken, Morgan A. Sammons, Pamela M. Odorizzi et al. · Science · 2016 · 1.2K citations · Full text

Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

Joseph L. Benci, Bihui Xu, Yu Qiu et al. · Cell · 2016 · 1.1K citations · Full text

Tumor Immunology, Multigenic Resistance Program, Cancer Immunosurveillance +11

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

Bertram Bengsch, Andrew L. Johnson, Makoto Kurachi et al. · Immunity · 2016 · 775 citations · Full text

Metabolic Alterations, Bioenergetic Insufficiencies Due, Signal Transduction +15