Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

Christina Twyman-Saint Victor, Andrew J. Rech, Amit Maity, +22

Nature

Cancer ImmunosurveillanceMedicineImmunologyNon-redundant Immune MechanismsImmune Checkpoint Inhibitor +7

Mitotic progression following DNA damage enables pattern recognition within micronuclei

Shane M. Harding, Joseph L. Benci, Jerome Irianto, +3

Nature

ChromatinGenome InstabilityDna DamageCell DivisionChromatin Remodeling +8

Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

Joseph L. Benci, Bihui Xu, Yu Qiu, +16

Cell

Tumor ImmunologyMultigenic Resistance ProgramCancer ImmunosurveillanceMedicineImmunology +9

Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

Joseph L. Benci, Lexus R. Johnson, Ruth Choa, +14

Cell

Immune EvasionCancer ImmunosurveillanceInterferon Coordinate AdaptiveInnate Immune SystemImmunology +10

Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer

Barzin Y. Nabet, Yu Qiu, Jacob E. Shabason, +8

Cell

ChromatinExosomesNatural SciencesMolecular BiologyCancer Genomics +8

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination

Sharanya Sivanand, Seth D. Rhoades, Qinqin Jiang, +12

Molecular Cell

BiosynthesisNatural SciencesProtein BiosynthesisMolecular BiologyDna Replication +5

Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses

Jie Chen, Shane M. Harding, Ramakrishnan Natesan, +6

Cell Reports

Cancer cells resistant to immune checkpoint blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction

Jingya Qiu, Bihui Xu, Darwin Ye, +9

Nature Cancer

Immunological MemoryCancer ImmunosurveillanceT Cell DysfunctionImmunologyImmune Checkpoint Inhibitor +9

Detoxification of Multiple Heavy Metals by a Half-Molecule ABC Transporter, HMT-1, and Coelomocytes of Caenorhabditis elegans

Marc S. Schwartz, Joseph L. Benci, Devarshi Selote, +5

PLoS ONE

Stereotactic Intracranial Implantation and <em>In vivo </em>Bioluminescent Imaging of Tumor Xenografts in a Mouse Model System of Glioblastoma Multiforme

Brian C. Baumann, Jay F. Dorsey, Joseph L. Benci, +2

Journal of Visualized Experiments

Tumor XenograftsEngineeringOncologic ImagingMouse Model SystemBiomedical Engineering +20