Mitotic progression following DNA damage enables pattern recognition within micronuclei

Shane M. Harding, Joseph L. Benci, Jerome Irianto, +3

Nature

ChromatinGenome InstabilityDna DamageCell DivisionChromatin Remodeling +8

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

Takamasa Harada, Joe Swift, Jerome Irianto, +7

The Journal of Cell Biology

EngineeringMechanical EngineeringCytoskeletonBiomedical EngineeringStem Cell Migration +18

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

Amnon Buxboim, Joe Swift, Jerome Irianto, +8

Current Biology

MechanobiologyCell-matrix InteractionCell MotilityCell BiomechanicsCytoskeleton +7

DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration

Jerome Irianto, Yuntao Xia, Charlotte R. Pfeifer, +9

Current Biology

ChromatinGenome InstabilityDna DamageMedicineGenetics +10

Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest

Sang-Kyun Cho, Manasvita Vashisth, Amal Abbas, +13

Developmental Cell

MechanobiologyChromatinGenome InstabilityLamina ProtectsEngineering +13

Nuclear rupture at sites of high curvature compromises retention of DNA repair factors

Yuntao Xia, Irena L. Ivanovska, Kuangzheng Zhu, +11

The Journal of Cell Biology

Dna DamageNuclear StructureNuclear RuptureGeneticsDna Analysis +19

Nuclear lamin stiffness is a barrier to 3D-migration, but softness can limit survival

Takamasa Harada, Joe Swift, Jerome Irianto, +7

EngineeringMolecular BiologyCytoskeletonBiomedical EngineeringStem Cell Migration +19

Constricted migration increases DNA damage and independently represses cell cycle

Charlotte R. Pfeifer, Yuntao Xia, Kuangzheng Zhu, +9

Molecular Biology of the Cell

Nuclear constriction segregates mobile nuclear proteins away from chromatin

Jerome Irianto, Charlotte R. Pfeifer, Rachel R. Bennett, +5

Molecular Biology of the Cell

Osmotic Challenge Drives Rapid and Reversible Chromatin Condensation in Chondrocytes

Jerome Irianto, Joe Swift, Rui Pires Martins, +4

Biophysical Journal

ChromatinDevelopmental BiologyBone Morphogenic ProteinChromatin RemodelingCartilage Degeneration +4