Sasikanth Manne

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Divij Mathew, Josephine R. Giles, Amy E. Baxter et al. · Science · 2020 · 1.6K citations · Full text

T-cell invigoration to tumour burden ratio associated with anti-PD-1 response

Alexander C. Huang, Michael A. Postow, Robert J. Orlowski et al. · Nature · 2017 · 1.6K citations · Full text

Burden Ratio, Cancer Immunosurveillance, Medicine +8

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

Omar Khan, Josephine R. Giles, Sierra McDonald et al. · Nature · 2019 · 1.5K citations

Transcriptional Regulation, T-regulatory Cell, Gene Expression +3

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Kristen E. Pauken, Morgan A. Sammons, Pamela M. Odorizzi et al. · Science · 2016 · 1.2K citations · Full text

Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

Jean‐Christophe Beltra, Sasikanth Manne, Mohamed S. Abdel-Hakeem et al. · Immunity · 2020 · 974 citations · Full text

Chromatin, Transcriptional Regulation, Lineage Plasticity +11