PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia

Fabienne McClanahan, Bola S. Hanna, Shaun Miller, +4

Blood

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme

Weijun Feng, Daisuke Kawauchi, Huiqin Körkel-Qu, +23

Nature Communications

Depletion of CLL-associated patrolling monocytes and macrophages controls disease development and repairs immune dysfunction in vivo

Bola S. Hanna, Fabienne McClanahan, Haniyeh Yazdanparast, +9

Leukemia

InflammationAutoimmune DiseaseImmune Cell DevelopmentImmune RegulationImmunology +6

Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity

Bola S. Hanna, Laura Llaó Cid, Murat Iskar, +21

Immunity

InflammationImmune EvasionCancer ImmunosurveillanceImmunologyTumor Immunity +8

The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries

Bola S. Hanna, Gang Wang, Silvia Galván-Peña, +7

Immunity

InflammationDysbiosisMucosal ImmunologyDistal Tissue RegenerationImmune Cell Development +11

Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton

Peter Boldsen Knudsen, Bola S. Hanna, S. Öhl, +7

Leukemia

Hematological MalignancyMalignant Blood DisorderApoptosisImmunologyCell Death +6

Control of chronic lymphocytic leukemia development by clonally-expanded CD8+ T-cells that undergo functional exhaustion in secondary lymphoid tissues

Bola S. Hanna, Philipp M. Roessner, Haniyeh Yazdanparast, +9

Leukemia

Lymphoid NeoplasiaDevelopmental BiologyLymphocyte DevelopmentMalignant Blood DisorderImmunology +8

PI3Kδ inhibition modulates regulatory and effector T-cell differentiation and function in chronic lymphocytic leukemia

Bola S. Hanna, Philipp M. Roessner, Annika Scheffold, +6

Leukemia

Hematological MalignancySignal TransductionEffector T-cell DifferentiationChronic Lymphocytic LeukemiaCell Regulation +6

EOMES is essential for antitumor activity of CD8+ T cells in chronic lymphocytic leukemia

Laura Llaó Cid, Philipp M. Roessner, Vicente Chapaprieta, +10

Leukemia

A dynamic atlas of immunocyte migration from the gut

Silvia Galván-Peña, Yangyang Zhu, Bola S. Hanna, +2

Science Immunology