Mechanisms and optimization of in vivo delivery of lipophilic siRNAs

Christian Wolfrum, Shuanping Shi, K. N. Jayaprakash, +11

Nature Biotechnology

Cell-based Drug DeliveryNanomedicineEngineeringBiochemistryNano-drug Delivery +5

Regulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-6

Katsutoshi Ozaki, Rosanne Spolski, Rachel Ettinger, +10

The Journal of Immunology

A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1

Wei Li, Saiyu Hang, Yuan Fang, +13

Cell Host & Microbe

Signal TransductionBiochemistryBiliary TractNatural SciencesPhysiology +6

Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing

Zhoufeng Wang, Zhe Li, Kun Zhou, +16

Nature Communications

Arginine functionalized peptide dendrimers as potential gene delivery vehicles

Kui Luo, Caixia Li, Li Li, +3

Biomaterials

Peptide EngineeringPeptide ScienceTherapeuticsMedicineBiomolecular Engineering +1

Peptide dendrimers as efficient and biocompatible gene delivery vectors: Synthesis and in vitro characterization

Kui Luo, Caixia Li, Gang Wang, +4

Journal of Controlled Release

Vitro CharacterizationEngineeringPeptide EngineeringPeptide SciencePeptide Therapeutics +6

The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries

Bola S. Hanna, Gang Wang, Silvia Galván-Peña, +7

Immunity

InflammationDysbiosisMucosal ImmunologyDistal Tissue RegenerationImmune Cell Development +11

Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity

Chaoran Li, Gang Wang, Pulavendran Sivasami, +4

Cell Metabolism

T-regulatory CellImmune RegulationImmunologyInnate ImmunityImmune System +14

miR-203, a Tumor Suppressor Frequently Down-regulated by Promoter Hypermethylation in Rhabdomyosarcoma

Yarui Diao, Xing Guo, Lei Jiang, +5

Journal of Biological Chemistry

Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling

Paolo Cadinu, Kisha N. Sivanathan, Aditya Misra, +18

Cell

InflammationMucosal ImmunologyMedicineGastroenterologyPathology +6