Concepedia

Clonal Exhaustion

Clonal Exhaustion is a state of T cell dysfunction arising during chronic antigen exposure, characterized by the progressive loss of effector functions, sustained expression of inhibitory receptors, and diminished proliferative capacity, thereby preventing effective immune clearance of persistent pathogens or tumors.

42

Publications

4.4K

Citations

281

Authors

100

Institutions

Publications per year

2017–2026

14

Parents

Publications

42

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

Bertram Bengsch, Makoto Kurachi, Pamela M. Odorizzi et al. · Immunity · 2016 · 829 citations · Full text

, , +17

Apoptotic Death of CD8+ T Lymphocytes After Immunization: Induction of a Suppressive Population of Mac-1+/Gr-1+ Cells

Vincenzo Bronte, Michael Wang, Willem W. Overwijk et al. · The Journal of Immunology · 1998 · 318 citations · Full text

, , +17

Immune tolerance in liver disease

Ian Nicholas Crispe · Hepatology · 2014 · 267 citations · Full text

, , +17

Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8 <sup>+</sup> T cells

Anthony Kusnadi, Ciro Ramírez-Suástegui, Vicente Fajardo et al. · Science Immunology · 2021 · 249 citations · Full text

, , +17

Divergent clonal differentiation trajectories of T cell exhaustion

Bence Dániel, Kathryn E. Yost, Sunnie Hsiung et al. · Nature Immunology · 2022 · 229 citations · Full text

, , +14

1–5 of 42

Authors

281

  1. EJ
    E. John Wherry

    University of Pennsylvania, United States

    4 publications · 1.2K citations

    4

    h-index

  2. JR
    Josephine R. Giles

    University of Pennsylvania, United States

    3 publications · 345 citations

    3

    h-index

  3. RM
    Raymond M. Welsh

    University of Massachusetts Chan Medical School, United States

    3 publications · 320 citations

    3

    h-index

  4. BD
    Bence Dániel

    Stanford University, United States

    2 publications · 249 citations

    2

    h-index

  5. JA
    Julia A. Belk

    Stanford University, United States

    2 publications · 249 citations

    2

    h-index

1–5 of 281

Institutions

100

  1. University of Pennsylvania

    Philadelphia, United States

    5 h-index

    40 publications

    11.3K citations

  2. University of Massachusetts Chan Medical School

    Worcester, United States

    4 h-index

    7 publications

    504 citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    11 publications

    1.3K citations

  4. Parker Institute for Cancer Immunotherapy

    San Francisco, United States

    3 h-index

    10 publications

    1.2K citations

  5. University of Washington

    Seattle, United States

    3 h-index

    12 publications

    1.1K citations

  6. Translational Therapeutics (United States)

    Arlington, United States

    3 h-index

    7 publications

    786 citations

  7. Massachusetts General Hospital

    Boston, United States

    2 h-index

    8 publications

    305 citations

  8. Washington University in St. Louis

    St Louis, United States

    2 h-index

    5 publications

    727 citations

1–8 of 100

Venues

  1. Journal of Virology

    JVI · 4 publications · 423 citations

    4

    h-index

  2. The Journal of Immunology

    JI · 4 publications · 413 citations

    4

    h-index

  3. EBioMedicine

    2 publications · 176 citations

    2

    h-index

  4. Blood

    2 publications · 191 citations

    2

    h-index

  5. Cancer Cell

    2 publications · 207 citations

    2

    h-index

1–5