Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling

Evan W. Weber, Kevin R. Parker, Elena Sotillo, +23

Science

Engineering circular RNA for enhanced protein production

Robert Chen, Sean K. Wang, Julia A. Belk, +7

Nature Biotechnology

Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

Nathan E. Reticker-Flynn, Weiruo Zhang, Julia A. Belk, +22

Cell

Immune EvasionCancer ImmunosurveillanceDistant MetastasisMedicineImmunology +8

Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

Julia A. Belk, Winnie Yao, Nghi Ly, +17

Cancer Cell

ChromatinChromatin RemodelingGeneticsGenome-wide Crispr ScreensGene Editing +7

ecDNA hubs drive cooperative intermolecular oncogene expression

King L. Hung, Kathryn E. Yost, Liangqi Xie, +31

Nature

ChromatinEcdna HubsMolecular ResearchNatural SciencesDna Replication +4

Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

Kelly Kersten, Kenneth H. Hu, Alexis J. Combes, +11

Cancer Cell

Cancer ImmunosurveillanceT-regulatory CellImmunologyImmunologic MechanismCd8+ T Cells +6

Measurements and Performance Factor Comparisons of Magnetic Materials at High Frequency

Alex J. Hanson, Julia A. Belk, Seungbum Lim, +2

IEEE Transactions on Power Electronics

Magnetic PropertiesEngineeringMechanical EngineeringMagnetic ResonanceHigh Frequency +18

Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions

Ryan A. Flynn, Julia A. Belk, Yanyan Qi, +16

Cell

Viral ReplicationMedicineMass SpectrometryViral PathogenesisMolecular Biology +9

RASA2 ablation in T cells boosts antigen sensitivity and long-term function

Julia Carnevale, Eric Shifrut, Nupura Kale, +30

Nature

Divergent clonal differentiation trajectories of T cell exhaustion

Bence Dániel, Kathryn E. Yost, Sunnie Hsiung, +14

Nature Immunology

Lymphocyte DevelopmentT-regulatory CellT Cell ExhaustionMedicineCell Biology +2