Divergent clonal differentiation trajectories of T cell exhaustion

Bence Dániel, Kathryn E. Yost, Sunnie Hsiung, +14

Nature Immunology

Lymphocyte DevelopmentT-regulatory CellT Cell ExhaustionMedicineCell Biology +2

IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells

Natasha C. Ward, Aixin Yu, Alejandro Moro, +11

The Journal of Immunology

Purification and properties of the biotin repressor. A bifunctional protein.

M A Eisenberg, Om Prakash, Sunnie Hsiung

Journal of Biological Chemistry

BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4+ T cell responses to persistent antigen

Yu Xia, Katalin Sándor, Joy A. Pai, +13

Immunity

Autoimmune DiseaseAdaptive Immune SystemT-regulatory CellImmunologyAutoimmunity +7

Runx1 and Cbfβ regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder

Ansuman T. Satpathy, Carlos G. Briseño, Xiongwei Cai, +6

Blood

Persistent IL-2 Receptor Signaling by IL-2/CD25 Fusion Protein Controls Diabetes in NOD Mice by Multiple Mechanisms

Natasha C. Ward, Jen Bon Lui, Rosmely Hernandez, +8

Diabetes

High-dose IL-2/CD25 fusion protein amplifies vaccine-induced CD4⁺ and CD8⁺ neoantigen-specific T cells to promote antitumor immunity

Rosmely Hernandez, Kathryn M LaPorte, Sunnie Hsiung, +2

Journal for ImmunoTherapy of Cancer

Mode of action of the biotin antimetabolites actithiazic acid and alpha-methyldethiobiotin

MA Eisenberg, Sunnie Hsiung

Antimicrobial Agents and Chemotherapy

Bioorganic ChemistryBiotin A OperonBacteriologyEscherichia ColiChemical Biology +17

Dynamic transcriptional activity and chromatin remodeling of regulatory T cells after varied duration of interleukin-2 receptor signaling

Alejandro Moro, Zhen Gao, Lily Wang, +7

Nature Immunology

InflammationCytokineTranscriptional RegulationDynamic Transcriptional ActivityAutoimmune Disease +11

Sustained IL-2R signaling of limited duration by high-dose mIL-2/mCD25 fusion protein amplifies tumor-reactive CD8+ T cells to enhance antitumor immunity

Rosmely Hernandez, Kevin H. Toomer, Janika Põder, +3

Cancer Immunology Immunotherapy

Cancer ImmunosurveillanceMedicineImmunologyTumor ImmunityAntitumor Immunity +5